PRED-COUPLE input Page

PRED-COUPLE: a method that implements refined profile Hidden Markov Models to predict the coupling specificity of G-protein coupled receptors to G-proteins

Version 1.00

Paste your sequence(s) here (in FASTA format):

The PRED-COUPLE system is based on a library of Refined profile Hidden Markov Models of high discriminative power.

The prediction is based on sequence features within GPCR's intracellular domains. However, no membrane topology prediction is done when querying the library.

Seven (7) transmembrane receptor signatures from the Pfam database version 14.00 are also applied in order to verify a true GPCR sequence. When a query sequence is not recognized as a 7 transmembrane receptor a message is shown.

For more information on the the PRED-COUPLE method, please consult the help page

Original paper :
"A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models"
Sgourakis N.G., Bagos P.G., Papasaikas P.G. and Hamodrakas S.J.BMC Bioinformatics, 6:104, 2005

PubMed