PRED-COUPLE: a method
implements refined profile Hidden Markov Models to predict the coupling specificity
of G-protein coupled receptors to G-proteins
sequence(s) here (in FASTA format):
The PRED-COUPLE system is based on a library of Refined profile
Hidden Markov Models of high discriminative power.
The prediction is based on sequence features within GPCR's
intracellular domains. However, no membrane topology prediction is done
when querying the library.
Seven (7) transmembrane receptor signatures from the Pfam database
version 14.00 are also applied in order to verify a true GPCR
sequence. When a query sequence is not recognized as a 7
transmembrane receptor a message is shown.
For more information on the the PRED-COUPLE method, please
consult the help page
Original paper :
"A method for the prediction of GPCRs coupling specificity to G-proteins using
refined profile Hidden Markov Models"
Sgourakis N.G., Bagos P.G.,
Papasaikas P.G. and Hamodrakas S.J.BMC Bioinformatics, 6:104, 2005