Example of input of the program |
ID CXB1_RAT STANDARD; PRT; 283 AA.
AC P08033;
DT 01-AUG-1988 (Rel. 08, Created)
DT 01-AUG-1988 (Rel. 08, Last sequence update)
DT 28-FEB-2003 (Rel. 41, Last annotation update)
DE Gap junction beta-1 protein (Connexin 32) (Cx32) (GAP junction 28 kDa
DE liver protein).
GN GJB1 OR CXN-32.
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=Liver;
RX MEDLINE=86251013; PubMed=3013898;
RA Paul D.L.;
RT "Molecular cloning of cDNA for rat liver gap junction protein.";
RL J. Cell Biol. 103:123-134(1986).
RN [2]
RP SEQUENCE OF 7-119 FROM N.A.
RC TISSUE=Liver;
RX MEDLINE=86301142; PubMed=3017758;
RA Heynkes R., Kozjek G., Traub O., Willecke K.;
RT "Identification of a rat liver cDNA and mRNA coding for the 28 kDa
RT gap junction protein.";
RL FEBS Lett. 205:56-60(1986).
CC -!- FUNCTION: ONE GAP JUNCTION CONSISTS OF A CLUSTER OF CLOSELY PACKED
CC PAIRS OF TRANSMEMBRANE CHANNELS, THE CONNEXONS, THROUGH WHICH
CC MATERIALS OF LOW MW DIFFUSE FROM ONE CELL TO A NEIGHBORING CELL.
CC -!- SUBUNIT: A CONNEXON IS COMPOSED OF A HEXAMER OF CONNEXINS.
CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC -!- SIMILARITY: BELONGS TO THE CONNEXIN FAMILY. BETA-TYPE (GROUP I)
CC SUBFAMILY.
DR EMBL; L36875; AAA75195.1; -.
DR PIR; A26278; GJRT.
DR InterPro; IPR000500; Connexin.
DR Pfam; PF00029; connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
KW Gap junction; Transmembrane.
FT DOMAIN 1 22 CYTOPLASMIC (POTENTIAL).
FT TRANSMEM 23 45 POTENTIAL.
FT DOMAIN 46 75 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 76 95 POTENTIAL.
FT DOMAIN 96 130 CYTOPLASMIC (POTENTIAL).
FT TRANSMEM 131 153 POTENTIAL.
FT DOMAIN 154 191 EXTRACELLULAR (POTENTIAL).
FT TRANSMEM 192 214 POTENTIAL.
FT DOMAIN 215 283 CYTOPLASMIC (POTENTIAL).
SQ SEQUENCE 283 AA; 32003 MW; C79FC46AA13BC5D7 CRC64;
MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS FICNTLQPGC
NSVCYDHFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH IEKKMLRLEG HGDPLHLEEV
KRHKVHISGT LWWTYVISVV FRLLFEAVFM YVFYLLYPGY AMVRLVKCEA FPCPNTVDCF
VSRPTEKTVF TVFMLAASGI CIILNVAEVV YLIIRACARR AQRRSNPPSR KGSGFGHRLS
PEYKQNEINK LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC
//
>CXB1_RAT
MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC
NSVCYDHFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEV
KRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCEAFPCPNTVDCF
VSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLS
PEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC