TABLE 7: Set of 148 proteins (MÖLLER- Non redundant set)

Name = Identification of the protein in SwissProt (ID and AC code)

len = length of the sequence

OTM = number of observed transmembrane segments

PTM = number of predicted transmembrane segments

Observed segments = boundaries of observed segments

Predicted segments = boundaries of predicted segments

NAME

len

OTM

PTM

Observed segments

Predicted segments

1B14_HUMAN P03989

361

1

2

309-332

8-25, 306-332

60IM_ECOLI P25714

548


4


346-372, 419-444, 463-479, 497-523

A15_HUMAN P41732

244

4

4

12-35, 52-70, 82-107, 209-229

9-43, 53-77, 79-102, 203-232

A4_HUMAN P05067

770

1

2

700-723

2-18, 700-718

ADT2_YEAST P18239

318

6

3

27-44, 89-107, 131-148, 192-210, 231-248, 287-305

126-146, 185-211, 223-241

ADTA_RICPR P19568

498

12

10

34-54, 68-88, 93-113, 148-168, 185-205, 219-239, 280-300, 321-341, 349-369, 380-400, 439-459, 466-486

64-82, 93-116, 138-168, 186-206, 219-235, 278-294, 322-348, 350-379, 381-396, 443-482

ALKB_PSEOL P12691

401

6

4

21-39, 42-62, 89-111, 114-134, 229-249, 251-270

27-62, 95-129, 228-263, 329-349

ARCD_PSEAE P18275

482

13

12

11-30, 40-61, 94-118, 126-145, 163-184, 204-221, 236-258, 281-305, 335-352, 365-389, 405-421, 428-444, 459-475

11-29, 31-61, 81-116, 118-145, 159-179, 201-218, 236-257, 276-313, 334-351, 365-387, 405-442, 458-481

ARSB_ECOLI P37310

429

12

11

7-26, 60-80, 93-111, 121-141, 149-168, 178-198, 221-241, 246-263, 280-299, 317-336, 351-371, 401-421

2-24, 26-48, 50-72, 93-128, 130-165, 175-194, 227-263, 277-301, 307-346, 375-390, 399-428

ATP6_ECOLI P00855

271

5

5

39-60, 106-127, 138-159, 205-227, 236-257

41-61, 100-123, 147-166, 211-241, 243-264

ATPL_ECOLI P00844

79

2

2

11-31, 53-73

8-33, 53-78

B3AT_HUMAN P02730

911

12

10

404-424, 437-456, 460-479, 491-510, 523-541, 569-588, 604-624, 661-680, 699-719, 763-780, 785-806, 844-865

403-421, 440-471, 486-513, 521-535, 571-588, 608-624, 659-682, 706-729, 763-803, 835-870

BACR_HALHA P02945

262

7

7

24-42, 57-75, 92-109, 121-140, 148-167, 186-204, 217-236

23-42, 61-79, 99-117, 121-136, 138-169, 190-207, 209-237

BCS1_YEAST P32839

456

1

1

45-68

50-68

BOFA_BACSU P24282

87

2

3

3-23, 37-57

3-27, 29-60, 62-86

CAN1_YEAST P04817

590

9

12

93-110, 115-134, 173-193, 236-255, 326-346, 420-440, 452-472, 499-518, 524-544

93-132, 134-149, 153-189, 194-220, 228-260, 283-305, 328-345, 377-397, 420-439, 451-470, 494-521, 523-548

CB22_PEA P07371

269

3

2

92-126, 160-180, 207-236

155-178, 223-239

CD7_HUMAN P09564

240

1

2

181-201

2-26, 173-201

CD81_HUMAN P18582

236

4

4

12-34, 64-84, 90-112, 202-224

9-35, 58-85, 87-114, 202-230

CITN_KLEPN P31602

446

12

12

23-43, 46-66, 79-99, 110-130, 148-168, 173-193, 213-233, 267-287, 289-309, 336-356, 363-383, 426-446

23-44, 46-66, 78-99, 116-132, 141-175, 177-193, 212-230, 269-291, 293-313, 336-351, 357-393, 427-445

CLC1_HUMAN P35523

988

11

12

118-137, 159-182, 206-227, 266-290, 305-323, 348-368, 391-414, 456-475, 478-496, 524-545, 553-572

118-135, 157-184, 211-230, 238-257, 265-290, 302-322, 348-368, 391-411, 447-477, 479-507, 515-548, 550-570

CNG1_BOVIN Q00194

690

3

3

163-184, 295-323, 372-400

162-178, 300-317, 373-398

COAB_BPFD P03617

73

1

1

48-68

43-62

COAB_BPPF1 P03621

82

1

2

56-78

20-39, 57-76

CODB_ECOLI P25525

419

12

11

20-39, 52-71, 101-120, 128-147, 153-172, 193-212, 222-242, 258-277, 301-320, 322-341, 359-378, 381-400

19-41, 43-79, 89-126, 128-162, 164-179, 193-210, 223-253, 255-281, 288-305, 307-341, 358-398

COX1_BOVIN P00396

514

12

12

12-40, 51-86, 95-117, 141-170, 183-212, 228-261, 270-286, 299-327, 336-357, 371-400, 407-433, 447-478

18-37, 56-90, 100-134, 136-169, 182-206, 234-254, 267-293, 308-325, 329-359, 371-400, 408-427, 452-473

COX2_BOVIN P00404

227

2

2

19-42, 60-83

28-46, 64-81

COX3_BOVIN P00415

261

7

6

16-34, 41-66, 73-105, 129-152, 156-183, 191-223, 233-256

15-49, 81-108, 129-144, 162-179, 190-220, 237-260

COX4_BOVIN P00423

169

1

1

99-124

103-120

COX4_PARDE P77921

50

1

1

17-48

24-48

COXD_BOVIN P07471

97

1

1

25-49

28-43

COXH_BOVIN P04038

73

1

1

12-52

19-35

COXK_BOVIN P07470

80

1

1

47-75

55-74

COXM_BOVIN P13183

88

1

1

41-67

48-70

COXO_BOVIN P00430

63

1

1

34-60

37-56

COXQ_BOVIN P10175

70

1

1

36-59

40-59

CP5A_CANTR P10615

543

1

1

29-48

29-43

CPXA_ECOLI P08336

457

2

2

8-29, 164-189

2-28, 163-184

CVAA_ECOLI P22519

413

1

1

21-36

7-38

CXB1_RAT P08033

283

4

4

21-40, 71-90, 130-150, 190-209

23-40, 74-93, 131-163, 192-214

CYB_RHOSH Q02761

444

8

10

49-66, 94-112, 129-148, 193-215, 252-269, 329-345, 364-381, 388-407

39-68, 94-112, 128-149, 151-185, 193-215, 241-270, 291-312, 314-348, 364-381, 390-413

CYDA_ECOLI P11026

522

7

9

23-42, 95-114, 130-149, 188-207, 220-239, 393-412, 471-490

12-42, 58-75, 91-118, 131-151, 188-208, 220-238, 383-409, 425-444, 465-494

CYDB_ECOLI P11027

379

8

8

9-28, 80-99, 123-142, 165-184, 206-225, 263-282, 293-312, 337-356

9-35, 62-99, 121-142, 161-185, 206-226, 259-278, 288-321, 335-360

CYOB_ECOLI P18401

663

15

14

17-35, 58-76, 102-121, 144-162, 195-213, 232-250, 277-296, 320-339, 348-366, 382-401, 410-429, 458-476, 495-513, 588-606, 614-632

14-41, 57-74, 105-129, 136-167, 189-213, 225-255, 268-298, 316-340, 342-364, 370-402, 404-441, 456-479, 494-514, 590-623

CYOC_ECOLI P18402

204

5

5

32-50, 67-85, 102-120, 143-161, 185-203

26-53, 66-91, 101-118, 138-162, 182-203

CYOD_ECOLI P18403

109

3

3

18-36, 46-64, 81-99

17-44, 46-66, 80-104

CYOE_ECOLI P18404

296

7

9

10-28, 38-56, 79-97, 108-126, 198-216, 229-247, 269-287

12-36, 38-56, 83-97, 99-124, 137-153, 155-175, 204-227, 229-249, 264-295

DCRA_DESVH P35841

668

1

2

188-207

11-33, 189-207

DCTA_RHIME P20672

441

12

9

31-49, 69-87, 100-118, 150-168, 172-190, 210-228, 242-260, 282-300, 321-339, 351-369, 379-398, 406-424

19-38, 54-74, 87-109, 141-178, 193-223, 225-257, 307-327, 339-353, 355-385

DHG_ECOLI P15877

796

5

5

11-37, 41-58, 63-81, 96-110, 119-141

15-49, 51-85, 87-101, 103-135, 695-727

DIVB_BACSU P16655

263

1

1

32-52

35-53

DMSC_ECOLI P18777

287

8

8

10-32, 44-66, 90-107, 115-134, 157-174, 183-201, 225-242, 255-280

7-32, 44-67, 87-107, 117-138, 143-171, 173-204, 223-244, 251-286

DSBB_ECOLI P30018

176

4

3

15-31, 50-65, 72-89, 145-163

13-38, 40-79, 142-162

DTPT_LACLA P36574

463

12

13

3-21, 31-49, 59-77, 82-100, 121-139, 148-166, 191-209, 221-239, 260-278, 302-320, 339-357, 392-410

3-23, 25-49, 52-68, 70-98, 121-141, 143-167, 191-214, 216-241, 256-274, 301-320, 337-357, 359-388, 430-451

EBR_STAAU P14319

107

4

4

3-20, 30-47, 57-75, 86-103

2-16, 29-46, 57-73, 75-104

ENVZ_ECOLI P02933

450

2

2

16-35, 162-182

12-41, 159-179

EXBB_ECOLI P18783

244

3

3

16-39, 128-155, 162-194

21-42, 131-167, 171-199

EXBD_ECOLI P18784

141

1

1

23-43

22-43

FDOH_ECOLI P32175

300

1

1

261-279

259-274

FDOI_ECOLI P32174

211

4

4

18-32, 54-72, 113-130, 152-170

19-48, 55-73, 113-142, 144-178

FLO1_HUMAN P41440

591

12

11

24-44, 71-89, 96-116, 124-144, 160-177, 187-203, 260-287, 310-327, 334-354, 361-378, 395-419, 434-454

70-94, 97-120, 122-137, 158-178, 180-203, 272-288, 311-327, 337-362, 367-383, 395-418, 434-452

FRDC_ECOLI P03805

131

3

3

22-49, 66-90, 105-128

33-51, 56-82, 113-130

FRDD_ECOLI P03806

119

3

3

9-35, 61-89, 97-115

12-47, 55-80, 99-118

FRIZ_DROME P18537

581

7

7

248-270, 281-303, 344-364, 381-401, 422-439, 472-492, 530-553

248-266, 281-303, 339-368, 384-405, 410-449, 472-492, 533-553

FTSH_ECOLI P28691

644

2

2

5-24, 96-120

5-19, 102-121

FUCP_ECOLI P11551

438

12

11

25-45, 56-76, 96-115, 119-139, 167-187, 207-227, 266-286, 296-316, 327-347, 353-373, 382-402, 414-434

24-41, 61-85, 92-109, 111-138, 161-178, 208-228, 294-315, 322-351, 353-369, 386-404, 414-429

GAB1_HUMAN P18505

474

4

3

246-267, 271-293, 305-327, 452-473

243-281, 308-327, 455-473

GEF_ECOLI P22982

50

1

1

6-24

6-24

GLPA_HUMAN P02724

150

1

2

92-114

4-27, 92-110

GLPT_ECOLI P08194

452

12

10

28-44, 65-87, 96-113, 120-136, 170-184, 191-209, 256-270, 293-310, 324-348, 356-378, 385-410, 419-438

30-46, 65-84, 94-142, 163-188, 190-208, 248-273, 322-341, 343-370, 384-405, 407-437

GP21_RAT P11654

1886

1

5

1806-1828

6-26, 485-503, 1119-1142, 1477-1508, 1803-1828

GSPL_PSEAE P25060

382

1

3

234-254

2-17, 234-252, 364-381

GSPM_PSEAE P25061

174

1

1

33-52

33-52

GSPN_ERWCA P31710

248

1

1

7-27

6-42

GSPP_PSEAE Q51575

235

1

1

31-51

31-56

HLYB_ECOLI P08716

707

8

4

38-51, 58-78, 158-179, 191-211, 269-289, 295-315, 388-408, 412-432

158-175, 191-211, 273-307, 388-425

HLYD_ECOLI P06739

478

1

1

60-80

59-80

HOXN_ALCEU P23516

351

8

7

20-40, 52-72, 95-115, 129-149, 200-220, 244-264, 270-290, 319-338

20-50, 89-112, 128-149, 195-212, 222-264, 276-297, 309-334

IM17_YEAST P39515

158

4

3

12-32, 59-79, 88-108, 113-133

17-32, 58-72, 118-132

IM23_YEAST P32897

222

4

1

97-130, 145-166, 175-189, 197-215

97-118

IMMA_CITFR P05701

178

4

4

14-37, 69-89, 106-123, 143-165

17-37, 72-87, 107-123, 142-168

KCSA_STRLI Q54397

160

2

2

28-47, 88-111

26-50, 81-111

KDGL_ECOLI P00556

121

3

2

33-48, 52-68, 95-118

35-71, 99-120

KDPD_ECOLI P21865

894

4

3

401-423, 428-444, 446-466, 475-498

401-437, 439-466, 470-494

KGTP_ECOLI P17448

432

12

11

26-54, 62-80, 96-116, 120-136, 163-185, 196-214, 244-261, 275-301, 312-330, 337-360, 369-392, 403-423

30-58, 62-84, 100-136, 166-183, 195-214, 244-262, 278-302, 312-332, 334-360, 371-389, 399-419

KPM1_ECOLI P23889

258

6

6

31-54, 62-81, 109-132, 144-165, 175-195, 227-247

30-59, 63-80, 110-137, 140-165, 174-196, 227-248

LACY_ECOLI P02920

417

12

10

11-33, 47-67, 75-99, 103-125, 145-163, 168-188, 218-241, 260-281, 291-310, 315-334, 347-366, 380-399

8-34, 46-66, 75-101, 103-125, 145-165, 167-192, 266-288, 291-310, 349-366, 368-406

LCND_LACLA Q00565

474

1

1

22-44

23-43

LECH_HUMAN P07306

290

1

1

40-60

40-59

LEP_ECOLI P00803

324

2

2

4-22, 59-77

3-22, 64-82

LEP4_ERWCA P31712

279

8

5

17-35, 105-123, 131-149, 164-182, 186-204, 215-233, 237-254, 258-276

10-35, 107-147, 160-199, 215-242, 257-278

LHA4_RHOAC P26789

53

1

1

14-34

9-45

LHB5_RHOAC P26790

41

1

1

15-36

21-40

LSPA_ECOLI P00804

164

4

4

12-26, 70-89, 96-113, 142-159

8-31, 60-88, 99-117, 137-153

LYSP_ECOLI P25737

488

12

12

21-41, 55-75, 104-124, 130-148, 160-180, 199-217, 244-263, 283-303, 347-364, 371-391, 415-432, 449-469

23-44, 46-77, 92-123, 125-148, 160-184, 192-219, 244-265, 285-317, 347-372, 374-390, 414-433, 446-466

MALF_ECOLI P02916

514

8

7

17-36, 40-58, 67-92, 276-306, 319-336, 370-392, 426-452, 484-506

17-58, 67-92, 276-306, 319-340, 371-392, 419-444, 483-504

MALG_ECOLI P07622

296

6

6

19-39, 82-102, 124-144, 151-171, 205-225, 260-280

17-42, 76-111, 124-148, 150-175, 205-233, 263-286

MELB_ECOLI P02921

469

12

11

16-36, 39-59, 77-97, 105-125, 150-170, 183-203, 232-252, 266-286, 296-316, 325-345, 378-398, 407-427

16-50, 72-92, 94-119, 140-158, 165-188, 231-258, 260-274, 292-316, 318-340, 363-394, 400-420

MNTB_SYNY3 Q55282

306

9

8

26-46, 49-69, 72-92, 102-122, 142-162, 180-200, 203-223, 229-249, 256-276

4-18, 22-53, 55-92, 102-124, 136-153, 184-217, 235-249, 251-27

MOTA_ECOLI P09348

295

4

4

2-23, 33-52, 170-192, 201-223

2-25, 27-48, 165-185, 198-224

MOTB_ECOLI P09349

308

1

1

28-49

28-49

MPRD_BOVIN P11456

279

1

2

188-213

2-19, 187-212

MSCL_ECOLI P23867

136

2

2

19-38, 70-96

19-52, 75-96

MSCL_MYCTU O53898

151

2

2

15-43, 69-89

14-32, 66-94

MTR_ECOLI P22306

414

11

10

11-34, 39-61, 87-109, 123-145, 152-174, 189-210, 228-251, 282-303, 322-341, 344-365, 387-409

2-29, 31-63, 89-114, 125-152, 154-175, 188-207, 228-249, 284-310, 326-367, 386-413

MYPR_HUMAN P06905

276

4

4

9-35, 63-87, 151-176, 233-259

2-35, 66-91, 151-180, 232-267

NNTM_BOVIN P11024

1086

14

14

475-493, 501-521, 527-546, 558-578, 596-616, 622-642, 646-666, 672-691, 702-722, 740-760, 778-797, 801-819, 833-853, 857-879

225-246, 478-514, 516-546, 548-577, 596-618, 620-647, 649-666, 672-688, 702-724, 740-761, 778-802, 804-819, 831-857, 859-893

NTG1_RAT P23978

599

12

13

53-73, 81-100, 124-144, 212-230, 239-256, 292-309, 321-342, 375-394, 422-440, 457-477, 498-517, 536-554

53-75, 78-107, 110-125, 127-152, 212-238, 240-264, 291-307, 321-346, 360-399, 422-447, 449-477, 492-522, 527-557

OPPB_SALTY P08005

306

6

6

10-30, 100-121, 138-158, 173-190, 227-250, 272-293

12-32, 94-121, 131-161, 163-190, 227-260, 272-293

OPSD_BOVIN P02699

348

7

7

37-63, 74-96, 111-133, 153-173, 203-224, 253-274, 287-308

34-57, 74-105, 107-133, 153-175, 203-228, 253-284, 287-301

OXA1_YEAST P39952

402

5

4

131-148, 201-218, 247-263, 276-291, 293-310

122-148, 200-218, 245-260, 282-308

PBP3_ECOLI P04286

588

1

3

24-40

24-45, 417-433, 540-558

PBPB_ECOLI P02919

844

1

1

64-87

64-87

PIGR_HUMAN P01833

764

1

2

639-661

2-16, 639-661

PMA1_NEUCR P07038

920

10

9

116-138, 141-160, 292-314, 322-354, 688-713, 721-738, 755-779, 807-825, 827-847, 854-878

116-134, 138-160, 286-314, 318-354, 688-709, 711-738, 755-779, 814-847, 854-878

PRRB_RHOSH Q53068

462

6

5

26-45, 52-70, 79-96, 104-123, 130-149, 165-182

23-41, 43-68, 83-122, 124-152, 159-181

PTMA_ECOLI P00550

637

6

9

25-44, 51-69, 135-154, 166-184, 272-291, 314-333

19-44, 51-66, 77-111, 128-157, 159-177, 213-235, 243-264, 266-300, 303-329

PTNC_ECOLI P08187

266

6

7

5-24, 50-69, 84-102, 106-124, 151-170, 182-201

6-21, 38-62, 64-80, 82-114, 138-164, 177-210, 212-239

PTND_ECOLI P08188

286

1

5

262-281

112-130, 132-163, 191-210, 237-258, 261-285

PUCC_RHOCA P23462

461

12

10

37-56, 63-83, 110-129, 143-163, 183-202, 210-228, 262-281, 303-319, 339-355, 359-376, 395-415, 437-456

39-60, 62-83, 109-131, 139-167, 179-203, 254-285, 302-316, 339-378, 390-417, 419-456

QACA_STAAU P23215

514

14

14

24-41, 58-75, 87-104, 113-130, 147-164, 173-190, 208-225, 238-255, 279-295, 316-333, 342-360, 370-387, 409-426, 482-499

20-43, 57-74, 90-112, 114-129, 145-171, 173-196, 210-227, 238-255, 281-297, 312-329, 333-361, 363-392, 415-433, 481-505

RAMP1_ECOLI O60894

148

1

1

120-139

118-139

RBSC_ECOLI P04984

321

6

8

23-43, 57-77, 126-145, 169-190, 221-240, 295-316

23-41, 52-83, 85-119, 121-144, 160-191, 221-237, 255-279, 281-316

RCEH_RHOVI P06008

258

1

1

12-30

10-25

RCEL_RHOVI P06009

273

5

6

32-52, 83-110, 115-138, 170-197, 225-248

21-57, 73-98, 111-151, 174-195, 224-250, 252-272

RHAT_ECOLI P27125

344

10

10

6-26, 37-57, 62-82, 97-117, 131-152, 175-195, 209-229, 255-275, 290-310, 322-342

3-26, 37-65, 67-92, 94-123, 133-151, 174-192, 201-234, 254-279, 292-310, 323-343

ROM1_BOVIN P52205

351

4

5

20-43, 65-84, 103-125, 265-286

2-16, 19-45, 47-80, 98-127, 263-290

SCAA_RAT P37089

699

2

3

110-139, 588-613

111-132, 575-607, 681-698

SECD_ECOLI P19673

615

6

5

10-29, 456-472, 477-497, 502-518, 564-580, 586-605

5-26, 456-480, 482-518, 556-571, 573-601

SECE_ECOLI P16920

127

3

3

19-36, 45-63, 93-111

19-36, 39-61, 95-125

SECY_ECOLI P03844

443

10

10

22-43, 78-98, 122-138, 158-175, 184-205, 215-238, 271-292, 314-336, 372-391, 396-419

23-44, 66-95, 125-141, 143-175, 182-204, 217-237, 271-304, 308-337, 373-388, 397-418

SSRG_RAT Q08013

185

4

4

28-48, 55-76, 136-157, 164-184

30-53, 55-77, 138-157, 166-181

STE6_YEAST P12866

1290

12

10

26-46, 76-96, 151-171, 174-194, 263-283, 297-317, 716-736, 764-784, 839-859, 866-886, 946-966, 982-1002

26-55, 76-93, 156-194, 249-279, 716-742, 762-779, 842-861, 863-886, 946-968, 981-999

SYB2_HUMAN P19065

115

1

1

94-112

94-114

TAL6_HUMAN P30408

202

4

4

10-30, 46-70, 89-116, 162-182

9-31, 46-70, 93-122, 162-194

TAL6_MOUSE Q64302

202

4

4

10-29, 48-69, 94-116, 162-182

9-31, 46-70, 93-111, 160-194

TCR2_ECOLI P02980

401

12

10

7-30, 43-61, 72-91, 99-119, 130-152, 159-178, 212-232, 244-265, 276-295, 299-322, 333-356, 366-387

7-27, 43-62, 78-115, 130-149, 151-179, 206-228, 239-266, 277-318, 336-357, 359-388

TOLA_ECOLI P19934

421

1

1

14-35

14-32

TOLR_ECOLI P05829

142

1

1

21-40

18-39

TONB_ECOLI P02929

239

1

1

2-32

14-30

TRD1_ECOLI P09130

717

2

2

28-47, 105-130

24-63, 107-130

TRSR_HUMAN P02786

760

1

2

68-88

66-89, 540-558

VG1_BPFD P03655

348

1

2

253-273

2-17, 253-267

VGLF_SENDZ P04855

565

1

3

501-523

117-135, 379-396, 501-523

VMT2_IAUDO P03490

97

1

1

25-42

25-43

VNB_INBLE P06817

100

1

1

19-40

17-40

VRXB_LAMBD P03759

144

4

4

8-26, 47-65, 86-104, 116-134

5-33, 48-66, 84-102, 104-134

VS10_ROTBN P08434

175

1

1

30-44

28-46