A Multiple Sequence Alignment Program
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Transformation table:


OBJECTIVE ( object.tbl )
::::::::::::::
A-CDEFGHI-KLMN-PQRST-VW-Y-
A-CDEFGHI-KLMN-PQRST-VW-Y-

Use this for objective alignments


HYDROPHOBE ( hydro.tbl )
::::::::::::::
A-CDEFGHI-KLMN-PQRST-VW-Y-
B-BAABBAB-ABBC-BCACC-BB-B-

Use this for sequence tarnsformation based on hydrophobicity


MEMBRANE ( membrane.tbl )
::::::::::::::
A-CDEFGHI-KLMN-PQRST-VW-Y-
I-IOOINOI-OIIO-NOONN-IN-N-

To take into account wether the residues belong to a transmembrane segment


STRUCTURE ( struct.tbl )
::::::::::::::
A-CDEFGHI-KLMN-PQRST-VW-Y-
H-ECDBTDB-DAAT-TBDTE-BB-E-

For transformation based on secondary structure preference

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Minimum length of an anchor:

The length that a conserved oligopeptide must have, in order to be an anchor. Must be at least one (1), and at most the shortest sequence length minus two.

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Gap penalty:

Small values can lead to long alignments and insertion of many 'gaps'. The recommended range is between 5 and 50.

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Objective alignment:

If you choose Yes, the alignment between the anchors will be based on the original (not transformed sequence).

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Minimum length of an obligatory anchor:

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Optimization of the between anchor alignment:

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Print transformed sequences:

Choose Yes to see the sequences after the transformation

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